Achievements

In vivo visualization of spontaneous activity in neonatal mouse sensory cortex at a single-neuron resolution.
Nakagawa-Tamagawa N*, Egashira T*, Rao MS, Mizuno H (*:Co–first authors)
Journal of Visualized Experiments 2023 Nov 21:(201)
Short-term dendritic dynamics of neonatal cortical neurons revealed by in vivo imaging with improved spatiotemporal resolution.
Wang L, Nakazawa S, Luo W, Sato T, Mizuno H, Iwasato T
eneuro 2023 Nov 7;10(11):ENEURO.0142-23.2023
In vivo two-photon calcium imaging of cortical neurons in neonatal mice.
Egashira T*, Nakagawa-Tamagawa N*, Abzhanova E*, Kawae Y, Kohara A, Koitabashi R, Mizuno Hir, Mizuno H (*:equal contribution)
STAR Protocols 2023 Apr 27;4(2):102245

In vivo investigations on Neurological Disorders: from traditional approaches to forefront technologies
Curia G, Camarena E.E., Manjarrez E, Mizuno H
Frontiers in Neuroscience 2022, 16:1052089
RasGAPs control neuronal circuit development in barrel cortex layer 4.
Rao MS, Mizuno Hir, Iwasato T, Mizuno H
Frontiers in Neuroscience 2022, 16:901774
https://www.frontiersin.org/articles/10.3389/fnins.2022.901774/abstract
Bone marrow imaging reveals the migration dynamics of neonatal hematopoietic stem cells
Takihara Y, Higaki T, Yokomizo T, Umemoto T, Ariyoshi K, Hashimoto M, Sezaki M, Takizawa H, Inoue T, Suda T, Mizuno H
Communications Biology 2022, 5 (1) 776
Live imaging of avian epiblast and anterior mesendoderm grafting reveals the complexity of cell dynamics during early brain development.
Yoshihi K, Kato K, Iida H, Teramoto M, Kawamura A, Watanabe Y, Nunome M, Nakano M, Matsuda Y, Sato Y, Mizuno H, Iwasato T, Ishii Y, Kondoh H
Development 2022, 149 (6): dev199999

NMDA receptor enhances correlation of spontaneous activity in neonatal barrel cortex
Mizuno H** (**Corresponding author), Rao MS, Mizuno H, Sato T, Nakazawa S, Iwasato T
The Journal of Neuroscience 2021, 41 (6) 1207-1217
Elucidating mechanisms of neuronal circuit formation in layer 4 of the somatosensory cortex via intravital imaging.
Rao MS, Mizuno H** (**Corresponding author)
Neuroscience Research 2021,167:47-53

Four-dimensional imaging with virtual reality to quantitatively explore jigsaw puzzle-like morphogenesis of Arabidopsis cotyledon pavement cells.
Higaki T**, Mizuno H** (**Corresponding authors)
Plant Biotechnology 2020 20.0605a
Developmental Phase Transitions in Spatial Organization of Spontaneous Activity in Postnatal Barrel Cortex Layer 4.
Nakazawa S, Yoshimura Y, Takagi M, Mizuno H, Iwasato T
The Journal of Neuroscience 2020 Sep 30;40(40):7637-7650.

High mitochondrial mass is associated with reconstitution capacity and quiescence of hematopoietic stem cells.
Takihara Y, Nakamura-Ishizu A, Tan DQ, Fukuda M, Matsumura T, Endoh M, Arima Y, Chin DWL, Umemoto T, Hashimoto M, Mizuno H, Suda T
Blood Advances 3(15) 2323-2327

In Vivo Two-photon Imaging of Cortical Neurons in Neonatal Mice
Mizuno H**, Nakazawa S, Iwasato T (**Corresponding author)
Journal of Visualized Experiments 140 e58340
Differential dynamics of cortical neuron dendritic trees revealed by long-term in vivo imaging in neonates.
Nakazawa S, Mizuno H, Iwasato T
Nature Communications 9(1) 3106
Patchwork-Type Spontaneous Activity in Neonatal Barrel Cortex Layer 4 Transmitted via Thalamocortical Projections.
Mizuno H**, Ikezoe K, Nakazawa S, Sato T, Kitamura K, Iwasato T** (**Corresponding authors)
Cell Reports 22(1) 123-135

Supernova: A Versatile Vector System for Single-Cell Labeling and Gene Function Studies in vivo
Luo W*, Mizuno H*, Iwata R, Nakazawa S, Yasuda K, Itohara S, Iwasato T(*Co–first authors)
Scientific Reports 6(Article number: 35747) 35747

Developmental RacGAP α2-Chimaerin Signaling Is a Determinant of the Morphological Features of Dendritic Spines in Adulthood
Iwata R, Matsukawa H, Yasuda K, Mizuno H, Itohara S, Iwasato T
The Journal of Neuroscience 35(40) 13728-13744

Transcallosal Projections Require Glycoprotein M6-Dependent Neurite Growth and Guidance.
Mita S, de Monasterio-Schrader P, Fünfschilling U, Kawasaki T, Mizuno H, Iwasato T, Nave KA, Werner HB, Hirata T
Cerebral Cortex (New York, N.Y. : 1991)
NMDAR-Regulated Dynamics of Layer 4 Neuronal Dendrites during Thalamocortical Reorganization in Neonates.
Mizuno H, Luo W, Tarusawa E, Saito YM, Sato T, Yoshimura Y, Itohara S, Iwasato T
Neuron 82(2) 365-379

Pre-synaptic and post-synaptic neuronal activity supports the axon development of callosal projection neurons during different post-natal periods in the mouse cerebral cortex.
Mizuno H, Hirano T, Tagawa Y
The European Journal of Neuroscience 31 410-424

Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade.
Ageta-Ishihara N, Takemoto-Kimura S, Nonaka M, Adachi-Morishima A, Suzuki K, Kamijo S, Fujii H, Mano T, Blaeser F, Chatila TA, Mizuno H, Hirano T, Tagawa Y, Okuno H, Bito H
The Journal of Neuroscience 29 13720-13729

Activity-dependent development of interhemispheric connections in the visual cortex.
Tagawa Y, Mizuno H, Hirano T
Reviews in the Neurosciences 19(1) 19-28

Evidence for activity-dependent cortical wiring: formation of interhemispheric connections in neonatal mouse visual cortex requires projection neuron activity.
Mizuno H, Hirano T, Tagawa Y
The Journal of Neuroscience : the official journal of the Society for Neuroscience 27 6760-6770
Interactions between plexin-A2, plexin-A4, and semaphorin 6A control lamina-restricted projection of hippocampal mossy fibers.
Suto F, Tsuboi M, Kamiya H, Mizuno H, Kiyama Y, Komai S, Shimizu M, Sanbo M, Yagi T, Hiromi Y, Chédotal A, Mitchell KJ, Manabe T, Fujisawa H
Neuron 53(4) 535-547